Satellite-retrieved methane (CH4) concentration data offers a valuable opportunity for large-scale emissions monitoring. However, its widespread adoption remains challenging due to the data volume and varying data quality. A workflow to estimate the methane emission rate of major hydrocarbon plays based on the mass balance principle using publicly available Sentinel-5P satellite data is presented. This workflow estimates the methane emission rate originating from specific regions. The proposed workflow is applied to estimate emissions from the Permian Basin and the Appalachian Basin in the United States. The results are compared against volumes estimated by other means and reported in the literature. The proposed method is easy to implement and offers promising potential for practical and reliable estimates for long-term regional methane emission monitoring purposes.

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