This paper discusses the problems caused by gas hydrates during gas lift operations in deep-water and cold/arctic areas. Hydrate accumulations that plug the pipelines can interrupt normal production schedules and cause economic loss or even generate a safety risk if not properly handled. Low temperature, high pressure and the presence of water are required for hydrate formation in oil and gas production systems. Here we study the effects of produced gas composition on gas hydrate formation. The presence of acid gas and large hydrocarbon gas molecules tend to facilitate hydrate formation. Injection source well candidates for gas lift are screened based on gas composition. Also, methods to detect hydrate formation in the pipeline will be investigated. Finally, best field practice to prevent hydrate plugs during gas lift operation will be recommended.