In this paper, integrated techniques have been developed to optimize performance of the hybrid steam-solvent injection processes in a depleted post-CHOPS reservoir with consideration of wormhole networks and foamy oil flow. With the experimentally determined properties of injected gases and reservoir fluids by performing PVT tests, history matching of the reservoir geological model is completed through the relationship between fluid and sand production profiles and reservoir pressure. Meanwhile, the wormhole network has been inversely determined with the newly developed pressure-gradient-based (PGB) sand failure criterion. Once the history matching is completed, the calibrated reservoir geological model is used to optimize the solvent(s) and CO2 concentrations, provided that thermal energy, injection rates, and flowing bottomhole pressures are chosen as the controlling variables. The genetic algorithm has been modified and used to maximize the objective function of net present value (NPV) while delaying the displacement front as well as extending the reservoir life with optimal oil recovery under various strategies. Depending on the formation pressure and temperature, soaking time is optimized as a function of solvent concentration and fluid properties. Subsequently, considering the wormhole network and foamy oil flow, such a modified algorithm can be used to allocate and optimize the production-injection strategies with the NPV as the objective function.