The paper presents the results of a multiparametric analysis of the helium saturation zone after its injection into a porous gas reservoir, the dynamics of its content in a withdrawn gas mixture and the helium recovery factor (target parameters). The calculations are performed on a three-dimensional composite hydrodynamic sector model of a homogeneous anisotropic reservoir of a virtual gas deposit. Based on the results obtained, the geological and technological factors are ranked according to the absolute value of the change of target parameters when the input parameters change. The dynamics of the influence of geological and technological factors on the target parameters is described concerning different withdrawn gas volume from the initial reserves. The identified relationships can be useful for planning of the experimental helium injection and the placement of exploitation wells at underground helium storage.