Strategy and tactics for remediation of salt-affected soils at exploration and production (E&P) sites continue to challenge the petroleum industry. Although substantial refinement of remediation technology is still required, an adequate database currently exists for the remediation of most sites. Permanent remediation (complete cure) requires correct measurement (examination), interpretation (diagnosis), and selection and application of the appropriate technology (prescription) for the specific physical, chemical, and cultural condition of each unique site (patient). Differences among spill circumstances include the volume and concentration of produced water spilled, the soil's texture, slope, stratification, erodibility, mineralogy, chemical characteristics, vegetation status, and drainage characteristics, as well as seasonal water table variation, site meteorological conditions, and corporate, regulatory, and landowner constraints. A decision-tree incorporating these and other variables will be presented in a forthcoming publication. Major factors of concern and emerging technologies are highlighted in this paper. Society of Petroleum Engineers, (SPE) members are invited to join in forming a national technical support network to provide a comprehensive and readily available database with which the petroleum industry can better examine, diagnose, prescribe, and cure salt-affected soil "patients."