In this paper, the use of various pressure measurements is investigated for determining formation pressure as well as permeability distribution by using the Multiprobe Formation Tester Packer and Probe Modules in horizontal wells. It is shown that reservoir pressure measurements along the wellbore give local as well as reservoir scale information about how the reservoir is being depleted and how cleanup takes place. The estimation of horizontal and vertical permeabilities. skin, and reservoir pressure along the wellbore is also presented by using interval (local) pressure transient tests. For the Multiprobe Formation Packer and Probe Modules in horizontal wells, an interpretation methodology is presented for determining the reservoir parameters. A few interval pressure transient test examples are presented for both formation pressure and permeability distribution.