The paper reviews two case histories about successful wellbore isolation with a suitable cementing system for a recent enhanced oil recovery / CO2 project targeting the Thamama B formation of the Bab Far North reservoir in the UAE. The first two wells were vertical observers with zonal isolation required between the Thamama A and B. These wells were expected to exhibit a naturally corrosive environment (e.g. 56,000 ppm of CO2). To address these challenges, a fit-for-purpose cementing system, suitable for CO2 and other corrosive fluids, was developed and successfully applied. The system was designed to isolate and protect specific Thamama zones and wellbore areas that contained gaseous or liquid corrosive CO2. This cement slurry was developed with a density of 16.7 ppg exhibiting expanding properties after setting to compensate potential shrinkage issues and to improve cement bond. Laboratory test results for the developed cementing system, such as compressive strength development, thickening time, expanding properties after setting, and integrity after long term exposure towards wet CO2, are presented and discussed. Performance requirements for cementing sytems to qualify for CO2 tolerance are elucidated. Finally, the execution in the field and the quality of the cement job was evaluated. All of the special designs exhibited excellent bond log results. The favorable lab test results and the positive case history conclude that the developed cementing system can be a viable solution to provide long term zonal isolation in a wellbore with a corrosive environment.