The present work studies the influence of the orientation of single and two-phase injection nozzles on the flow properties. Numerical simulations are performed to investigate single phase liquid injection in counter-current (negative angle), orthogonal and co-current (positive angle) flow configurations. The two-phase flow problem is studied experimentally. The data show that, for all gas and liquid flow rates, the combined effects of all three components of pressure drop provoke the highest total pressure drop in the counter-current flow configuration. Turbulence losses are shown to be the dominant effect in the two-phase problem.