HIV/AIDS continues to pose serious challenges to sustainable development, especially in developing nations and communities. The Bayelsa State of Nigeria is one state with an emerging HIV/AIDS epidemic. The Bayelsa State Action Committee on AIDS (BSACA) was the state body responsible for coordinating the response, however at the time of the study it had nor developed a strategic plan to address the epidemic. Against this background, the Shell Petroleum Development Company (SPDC) contracted Family Health International (FHI) to assist the State Government to develop a five year State Strategic Framework (SSF) for a comprehensive and sustainable response to the HIV/AIDS epidemic. Processes leading to the development included a desk review, formative assessment and training of stakeholders on technical strategies for an expanded comprehensive response (ECR). The SSF enabled the State to coordinate the use of resources and for every community to develop a strategic framework for a sustainable response to the HIV/AIDS epidemic.