As the number of wells drilled in regions with existing producing wells increases, understanding the detrimental impact of these by the depleted zone around parent wells becomes more urgent and important. This understanding should include being able to predict the extent and heterogeneity of the depleted region near the pre-existing wells, the resulting altered stress field, and the effect of this on newly created fractures from adjacent child wells. In this paper we present a workflow that addresses the above concern in the Eagle Ford shale play, using numerical simulations of fracturing and reservoir flow, to define the effect of the depletion zone on child wells and match their field production data. We utilize an ultra-fast hydraulic fracture and depletion model to conduct several hundred numerical simulations, with varying values of permeability and surface area, seeking for cases that match the field production data. Multiple solutions exist that match the field data equally well, and we used additional field production data of parent-child well-interaction, to select the most plausible model. Results show that the depletion zone is strongly non-uniform and that large reservoir regions remain undepleted. We observe two important effects of the depleted zone on fractures from child wells drilled adjacent to the parents. Some fractures propagate towards low pressure zones and do not contribute to production. Others are repelled by the higher stress region that develops around the depletion zone, propagate into undepleted rock, and have production rates commensurate to that from other child wells drilled away from depleted region. The observations are validated by the field data. Results are being used to optimize well placement and well spacing for subsequent field operations, with the objective to increase the effectiveness of the child wells.