Unconventional saline aquifers have injectivity problems due to low to moderate permeability, thickness and porosity, of the potential injection zones. Therefore, optimum injectivity rates to allow for more cost-effective sequestration requires enhancement techniques such as hydraulic fracturing of the injection zones and /or horizontal injection wells. This study presents analysis of different CO2 saline reservoir trapping and investigates the effect of well orientation on the CO2 injection rates and cumulative storage. Reservoir simulation is used to study the effect of well orientation on injectivity, based on reservoir and core data from a water saturated formation/saline aquifer in Western Australia. The results highlight benefits of using horizontal well over vertical well in improving the efficiency with which the CO2 will fill the reservoir (E - Factor).