Despite the numerous experimental studies, there is a lack of fundamental understanding about how the local and global heterogeneity control the efficiency of polymer flooding. In this work a series of water and polymer injection processes are performed on five-spot glass micromodels which are initially saturated with the crude oil at varying conditions of flow rate, water salinity, polymer type and concentration. Three different pore structures in combine with different layer orientations are considered for designing of five different micromodel patterns. It has been observed that the oil recovery of water flooding is increasing with the salinity concentration, for the ranges studied here. While, it shows there is an optimum value of concentration in which maximize the oil recovery in polymer flooding. The results confirmed that the highest oil recovery is obtained when the layers are perpendicular to the mean flow direction for both water and polymer flooding. Also, the oil recovery in polymer flooding increases with the increase of layer inclination angle, however it does not increase for waterflooding. In addition, the oil recovery is strongly affected by the local heterogeneity which is near injection zone. This study demonstrates the applicability of micromodel for studying of enhanced oil recovery techniques in locally and globally heterogeneous five-spot models.