A deep insight into tight gas transient flow behavior is important for understanding the production behavior of tight gas reservoirs. In this work, we constructed a two-dimensional model to illustrate one methodology of evaluating effective permeability of fractured flow media. Pulse-decay experiments on one fractured core to study porosity and permeability for both matrix and the fracture, under a series of pore pressure and effective stress. Based on the results, the approach proposed in this study has the advantage over the steady-state method that can capture the character of transient flow if the fracture network penetrates the core. The transient gas propagation in the matrix, fractured cored with the fracture width of 1 μm and 1 cm are in shapes of piston-like, arrow-like, and dumbbell-like, respectively. Though the fracture width is only 1 μm, it reduces the time to reach pressure equilibrium to about one-fourth and the effective permeably ratio is 3.98. Totally 59 pulse-decay experiments were performed on one fractured core. We successfully history matched all the pulse-decay experiments on a fractured core by a commercial simulator with the Global Match Error (GME) less than 0.2%, that the readers can readily adopt this approach. Based on the history matching of upstream and downstream pressure curves, the fracture permeability and porosity are 6 orders’ and 1 order's magnitude higher than the matrix. The matrix permeability is the most sensitive to the pore pressure and effective stress, and no consistent trend is observed for the fracture permeability and porosity as the pore pressure and effective stress change.