High-tech manufacturing, production and transportation of hazardous substances in the oil and gas mining are a serious threat to the environment and health of the workers. Most of oil and gas fields are located in remote regions, and therefore the shift work method is applied. This work form requires the group isolation. What contributes to the special attention to the human factor in ensuring safety at oil and gas fields. One way to solve this problem is to define and manage the psychological risks of oil and gas workers. The psychological risk is the probability of professional destruction and formation of unfavorable functional states of shift workers owing to prolonged negative social and industrial factors and having a deficit of personal and environmental recourses. We have developed an approach of qualitative and quantitative risk assessment. Qualitative analysis is to identify the type of risk assessment and bases and quantification is performed by dividing the number of workers who experience the change in the psychological status, the total number of staff in an organization, and multiplied by 100%. The study identified downside risks to the health and development of stress in employees of different professional groups: operators of oil and gas, other operators, drivers, engineers and technical workers and service technicians (maximum different in terms of labor and skill requirements). Risk management should be based on three main areas: control, isolation and decline. The study was sponsored by the Russian President's grant for state support of young Russian scientists - PhD (MK-7500.2016.6).