Liners with slots or holes are broadly employed to increase the production of horizontal wells. However, as these openings at the casing wall can reduce its strength under mechanical loading, such as radial compression, axial tension and bending, the structural response of the liners must be properly studied. A numerical and experimental procedure has been developed to optimize liner geometries. Different liner conceptions, with varied arrangements of slots and holes have been proposed to study its structural response under mechanical loading. The proposed conceptions were analyzed with the aid of nonlinear three dimensional finite element models incorporating metal plasticity, contact behavior and large rotations. Experimental tests of liners with slots under radial compression and bending were accomplished. The finite element models were calibrated through the correlation of experimental and numerical results.