Novel low dosage hydrate inhibitors (LDHI) have been developed for applications in oil and gas fields. The new-generation inhibitors work as kinetic inhibitors that prevent hydrate formation encountered frequently in deepwater operations. These chemicals effectively inhibit hydrate formation regardless of the water cut in the system. They also exhibit a low toxicity that leads to very favorable environmental ratings. Valuable experience has been learned from recent laboratory studies as well as field trials with respect to the application limits and implementation techniques for these new products. The key to the overall success is a full integration of a good front-end design, a comprehensive deployment plan and an effective monitoring program. An overview of the chemistry of these new inhibitors along with their performance under simulated deepwater conditions is briefly discussed. In addition, the effect of LDHI on hydrate formation and the effect of pressure on LDHI performance are addressed.