Practices of marine shale gas exploration and development in south China have proved that formation overpressure is the main controlling factor of shale gas enrichment and an indicator of good preservation condition. Accurate prediction of formation pressure before drilling is necessary for drilling safety and important for sweet spots predicting and horizontal wells deploying. However, the existing prediction methods of formation pore pressures all have defects, the prediction accuracy unsatisfactory for shale gas development. By means of rock mechanics analysis and related formulas, we derived a formula for calculating formation pore pressures. Through regional rock physical analysis, we determined and optimized the relevant parameters in the formula, and established a new formation pressure prediction model considering P-wave velocity, S-wave velocity and density. Based on regional exploration wells and 3D seismic data, we carried out pre-stack seismic inversion to obtain high-precision P-wave velocity, S-wave velocity and density data volumes. We utilized the new formation pressure prediction model to predict the pressure and the spatial distribution of overpressure sweet spots. Then, we applied the measured pressure data of three new wells to verify the predicted formation pressure by seismic data. The result shows that the new method has a higher accuracy. This method is qualified for safe drilling and prediction of overpressure sweet spots for shale gas development, so it is worthy of promotion.

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