Steel Catenary Risers (SCRs) and Hybrid Risers (HRs) are the most common production riser systems used in deepwater. These concepts are field proven. SCRs and Steel Lazy Wave Risers (SLWRs), a specific configuration of SCR, have been widely used in Gulf of Mexico (GoM). HRs have also recently gained popularity in West of Africa, as the concept proves to be advantageous in harsh environments. This paper addresses the global structural response of various production risers attached to a Semi-submersible in GoM. The stress analysis was conducted based on the fundamental thoughts of SCR and HR. Thus, 26 different models of risers (HRs, SCRs, and SLWRs) were analyzed to investigate the impacts of the various critical considerations on the riser structure. Details of riser modeling, environmental data, and vessel particulars are described. A primary vortex induced vibration analysis was also conducted to assess the systems further. The studies stated above were evaluated using a dynamic analysis software, Orcaflex. An initial cost calculation was also done for a holistic approach for selection of riser. Finally, the results obtained from the analyses were assessed. The key findings and conclusions were described. As such, a suitable riser was determined.