In recent years, a new discrete element method (DEM)-based approach termed Bonded Block Models (BBM) has been used as a tool that can realistically simulate the mechanism of rock fracturing. In this approach, the idea is to capture the laboratory-driven, macro elastic parameters such as unconfined compressive strength and Young’s modulus by providing corresponding micro-mechanical parameters such as the elastic modulus of intact blocks and the stiffness of discontinuities. For that, it is essential to provide a set of input micro-mechanical properties prior to any BBM modeling. Since these parameters cannot be obtained from laboratory experiments, researchers generally apply calibration process, a complex and time-consuming process, to get a set of micro parameters that provides the target macro properties. In order to reduce the complexity of the calibration process, this paper applies Uniform Design (UD) to develop a series of empirical relationships between micro and macro properties. To verify the suggested equations, two sets of micro properties were measured using the developed equations to reproduce the macro properties of two different rocks of which laboratory properties are given. The macro parameters obtained from the numerical simulation were in good agreement with experimental observations confirming the reliability and the applicability of the developed equations.